![]() ![]() ![]() ![]() Because there are indications that some interventions might be more effective when applied in an early phase,1 an important focus of research is preclinical or early detection of the disease. Mild cognitive impairment Alzheimer's disease performance variability reaction times Introduction Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to irreversible neurological damage and dementia. We conclude that performance variability can be regarded as a useful preclinical marker for AD. Intra-individual variability and RT of the complex tasks are the best predictors for a-MCI and AD status, respectively. Although in a-MCI not all differences reached statistical significance, primarily the cognitive component of the RT is affected in a-MCI. The slowing in AD affects both the cognitive and the motor component, while performance variability mainly affects the cognitive component of the RT. Persons with cognitive deterioration demonstrated more intra-individual variability and more slowing than cognitively healthy elderly. ![]() Cognitively healthy elderly (n = 218), persons with amnestic MCI (a-MCI) (n = 29) and patients with AD (n = 50) were examined with RT tasks with increasing complexity, subdividing RT into a decision and a movement component. This study evaluated whether reaction times (RT) and performance variability are potential markers for the early detection of Alzheimer's disease (AD). Accepted for publication September 12, 2007. Byline: Ellen Gorus, MSc, PhD (Gerontology Department, Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel, Brussels, Geriatric Department, Universitair Ziekenhuis Brussel, Brussels) Rudi De Raedt, MSc, PhD (Department of Psychology, Ghent University, Brussels) Margareta Lambert, MD (Geriatric Department, Universitair Ziekenhuis Brussel, Brussels) Jean-Claude Lemper, MD (Foundation for Psychogeriatrics, Brussels) Tony Mets, MD, PhD (Gerontology Department, Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel, Brussels, Geriatric Department, Universitair Ziekenhuis Brussel, Brussels, cognitive impairment Alzheimer's disease performance variability reaction timesĢ04 Reaction Times and Performance Variability in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease SAGE Publications, Inc.200810.1177/0891988708320973 EllenGorus MSc, PhD Gerontology Department, Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel, Brussels Geriatric Department, Universitair Ziekenhuis Brussel, Brussels RudiDe Raedt MSc, PhD Department of Psychology, Ghent University, Brussels MargaretaLambert MD Geriatric Department, Universitair Ziekenhuis Brussel, Brussels Jean-ClaudeLemper MD Foundation for Psychogeriatrics, Brussels TonyMets MD, PhD Gerontology Department, Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel, Brussels Geriatric Department, Universitair Ziekenhuis Brussel, Brussels, Received July 05, 2007. ![]()
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